High Surface to Volume Ratio
Large surface areas generate a higher capacity of interaction
sites. This has important
implications for antigen delivery, improved bio-availability and controlled release.
Stable Colloidall Suspension
Our product demonstrates remarkable stable colloidal suspension. Stable colloidal suspension generates
better adsorption and homogeneity of
multi-component vaccine formulation
High Antigen Absorbtion
Our high antigen adsorption property is the manifestation of small crystallite size and high surface to volume ratios. Studies indicate that small crystallite size
induced a stronger antigen-specific antibody response.
High Purity
Trace metals are below
detection limits. Studies indicates that high amount of elemental impurities can affect vaccine stability
Material Data Sheet
Science
Adjuvants have a critical role in a vaccine formulation. Adjuvants are added to vaccines to produce faster, stronger and longer-lasting immune responses and to improve the overall potency of the vaccine. Adjuvants might potentially have additional advantages, such reducing vaccination frequency and per-vaccine antigen dose.
Aluminum Adjuvant
Aluminum adjuvants have been around for more than 50 years. They have a long record of safety. Commonly used aluminum adjuvants in licensed vaccines are aluminum oxyhydroxide and aluminum phosphate.
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Formulation of Vaccines With Aluminum Adjuvants
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Antigen adsorption to adjuvants mostly occurs via hydrophobic, electrostatic, and ligand exchange mechanisms. Adjuvant surface charge, adjuvant size, dose, aspect ratio, dispersion, sedimentation rate, elemental impurities, antigen net charge, buffer type, surfactant type, pH, microenvironment pH, functional group, multiple antigens, complex antigens, isotonicity are some of the crucial attributes that play a vital role in vaccine formulations.
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Aluminum-containing Combination Adjuvants
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The combination of immunostimulatory molecules and aluminum can have a more effective immune response. Toll-like receptors are excellent candidates for combination adjuvants for example CpG 1018 (Dyanavax Technologies Inc.).